simian virus 40 | Association Between Simian Virus 40 and Human Tumors

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simian virus 40*******SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that sometimes causes tumors in animals, but most often persists as a latent infection. SV40 has been widely . See moreThe hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled by the historical contamination of some batches of polio . See more

simian virus 40SV40 is capable of multiplicity reactivation (MR). MR is the process by which two or more virus genomes containing otherwise lethal damage . See moreSV40 is dormant and is asymptomatic in rhesus monkeys. The virus has been found in many macaque populations in the wild, where it rarely . See more

Due to its high tissue tropism, biotechnology companies seek to utilize modified SV40 based vectors as a viral vector for gene therapy. In these helper dependent virus See moreSV40 consists of an unenveloped icosahedral virion with a closed circular double-stranded DNA genome of 5.2 kb. The virion adheres to . See moreThe early promoter for SV40 contains three elements. The TATA box is located approximately 20 base-pairs upstream from the See moreSV40 was first identified by Ben Sweet and Maurice Hilleman in 1960 when they found that between 10 and 30% of polio vaccines in the US . See more

The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which . Simian virus 40 (SV40) is a monkey virus that was administered to human . Polio vaccines used in the late 1950s and early 1960s were contaminated . Simian virus 40 (SV40) is a small DNA tumor virus of monkey origin. .SIMIAN VIRUS 40. Go to: 1. Exposure Data. 1.1. Host range and tissue tropism. The .Association Between Simian Virus 40 and Human Tumors Simian virus 40 (SV40), a polyomavirus of rhesus macaque origin, was .

Simian vacuolating virus 40 (SV40) is a polyomavirus naturally occurring in macaques .Simian virus 40 (SV40) is known to cause tumourigenesis. The main types of tumour induced by SV40 in laboratory animals mirror the human cancers that have been found to contain SV40 DNA or the viral . Simian virus 40 (SV40) is a small DNA tumor virus of monkey origin. .Simian virus 40 (SV40) is a nonenveloped virus with an icosahedral capsid symmetry. The structural gene products include VP1, VP2, and VP3, that associate within the infected cell to form the 72 capsomers of the viral capsid. SV40 large tumor antigen (T-ag) is involved in the initiation of viral replication in permissive hosts and regulates the . Simian virus 40 (SV40), a polyomavirus of rhesus macaque origin, was discovered in 1960 as a contaminant of polio vaccines that were distributed to millions of people from 1955 through early 1963. SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of .simian virus 40 Association Between Simian Virus 40 and Human Tumors Simian virus 40 (SV40) is known to cause tumourigenesis. The main types of tumour induced by SV40 in laboratory animals mirror the human cancers that have been found to contain SV40 DNA or the viral oncoprotein. . During the past 4 years, polymerase chain reaction (PCR) assays have detected DNA sequences related to SV40 (an oncogenic simian polyomavirus) in a variety of human tissues, especially choroid plexus tumors, ependymomas, mesotheliomas, and osteosarcomas (1-7).These findings were supported by the isolation of infectious SV40 .Simian Virus 40 (SV40) is a nonenveloped, double stranded DNA virus in the Polyomavirus genus of the family Papovaviridae, which also includes the BK and JC polyomaviruses of humans. SV40 persists as a latent infection in kidney, CNS and circulating lymphocytes and transmission is thought to occur through direct contact with . In this Journal Club, Chelsey Spriggs discusses how the study of simian virus 40 (SV40) revealed a key sequence in the large T antigen that directs its transport into the cell nucleus, advancing .The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen. A m .Nature

Vaccine contamination with Simian vacuolating virus 40, known as SV40 occurred in the United States and other countries between 1955 and 1961. SV40 is a monkey virus that has the potential to cause cancer in animals and humans, although this is considered very unlikely and there have been no known human cases.Simian virus 40 (SV40) is a DNA virus isolated in 1960 from contaminated polio vaccines, that induces mesotheliomas, lymphomas, brain and bone tumors, and sarcomas, including osteosarcomas, in hamsters. These same tumor types have been found to contain SV40 DNA and proteins in humans. Mesotheliomas and brain tumors are the two tumor types .

Some of the polio vaccine administered from 1955–1963 was contaminated with simian virus 40 (SV40). The virus came from the monkey kidney cell cultures used to produce the vaccine. Most, but not all, of the contamination was in the inactivated polio vaccine (IPV). Once the contamination was recognized, steps were taken to eliminate it from .Simian virus 40 (SV40) is a small (45 nm) DNA-containing virus that establishes a lifelong, harmless, persistent infection in the kidney of its natural host, the Rhesus macaque. SV40 causes tumors in some rodents and confers tumorigenic .希勒曼等人于1960年发现，他们在用來生產脊髓灰質炎疫苗的恆河猴 .

Simian Virus 40 (SV40), the type member of the Polyomaviridae family, was discovered in the fifties of the previous century as a contaminating virus in the polio vaccines that in those days were produced in primary cells from macaques (3, 4). Since then, SV40’s DNA genome was the first animal virus genome to be characterized (5, 6).

Some of the polio vaccine administered from 1955–1963 was contaminated with simian virus 40 (SV40). The virus came from the monkey kidney cell cultures used to produce the vaccine. Most, but not all, of the .

Simian virus 40 (SV40) is a small (45 nm) DNA-containing virus that establishes a lifelong, harmless, persistent infection in the kidney of its natural host, the Rhesus macaque. SV40 causes tumors in some rodents and confers tumorigenic .希勒曼等人于1960年发现，他们在用來生產脊髓灰質炎疫苗的恆河猴 . Simian Virus 40 (SV40), the type member of the Polyomaviridae family, was discovered in the fifties of the previous century as a contaminating virus in the polio vaccines that in those days were produced in primary cells from macaques (3, 4). Since then, SV40’s DNA genome was the first animal virus genome to be characterized (5, 6). Simian virus 40 (SV40) is a small DNA tumor virus of monkey origin. This polyomavirus was administered to human populations mainly through contaminated polio vaccines, which were produced in naturally infected SV40 monkey cells. Previous molecular biology and recent immunological assays have indicated that SV40 is spreading in .

Background. Many studies have reported the presence of simian virus 40 (SV40) deoxyribonucleic acid (DNA) or protein in human brain tumors and bone cancers, malignant mesothelioma, and non-Hodgkin’s lymphoma. However, the small samples and lack of control groups in some reports have made it difficult to assess their reliability. Simian virus 40 (SV40) is a member of the Polyomaviridae, a family of viruses characterized by small icosahedral virions and a circular double-stranded DNA genome of about 5 kb.The SV40 genome .

Simian virus 40 (SV40) is a DNA virus isolated in 1960 from contaminated polio vaccines, that induces mesotheliomas, lymphomas, brain and bone tumors, and sarcomas, including osteosarcomas, in hamsters. These same tumor types have been found to contain SV40 DNA and proteins in humans. Mesotheliomas .

discovery of a new simian virus which grew in cynomolgus and rhesus monkey kidney cells without . 20–40 year latency period usually described for other human carcinogens: for example .

Simian virus 40 (SV40) is a small (45 nm) DNA-containing virus that establishes a lifelong, harmless, persistent infection in the kidney of its natural host, the Rhesus macaque. SV40 causes tumors in some rodents and confers tumorigenic . The inadvertent and unrecognized presence of simian virus 40 (SV40) in the commercial inactivated Salk poliovaccines administered between 1955 and 1963 resulted in the potential exposure of millions of individuals, in the United States and elsewhere, to this polyomavirus of the rhesus macaque [ 1 ]. Many of the monkeykidney . The simian virus 40 (SV40) genome is small (5.2 kb) and contains a limited coding capacity (see accompanying figure). It comprises three parts — a non-translated regulatory region of about 400 .

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simian virus 40|Association Between Simian Virus 40 and Human Tumors